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Un punto di incontro tra medicina e agricoltura: il “Molecular Pharming”

Vettore di clonazione: molecola di DNA in grado di trasportare
DNA inserito e atta ad essere perpetuata in una cellula ospite.

Bibliografia

ALBERINI,E.- PORCEDDU,A.- MARCONI G. - VERONESI F. 2005 - Produzione
di vaccini in pianta.

BRENNAN, F.R. ET AL. 1999 - Chimeric plant virus particles administered nasally or
orally induce systemic and mucosal immune responses in mice. J Virol, 73(2): pp. 930-8.
CRAMER, C.L. - BOOTHE,J.G.- OISHI, K.K. 1999 - Transgenic plants for thera-
peutic proteins: linking upstream and downstream strategies. Curr Top Microbiol
Immunol, 240: pp. 95-118.
CURTISS, R., - CRADINEAN, C.A. 1990 - Oral immunisation by transgenic plants.
World Patent Application, Wo, 1990.90 (02484).

GIDDINGS,G.- ALLISON,G.- BROOKS,D.- CRTEA, A. 2000 - Transgenic plants
as factories for biopharmaceuticals. Nature Biotechnol. 18:p. 1151-1155.

HAQ, T.A., ET AL. 1995 - Oral immunization with a recombinant bacterial antigen
produced in transgenic plants [see comments]. Science. 268(5211): pp. 714-6.
KAPUSTA,J. ET AL. 1999 - A plant-derived edible vaccine against hepatites B virus.

MC GRAVEY,P.- HAMMOND J. - DIENELT, M.M. - HOOPER,DC.- FU, Z.F. -
DIETZSCHOLD ,B.- KIPROWSKY,H.- MICHAELS FH. 1995 - Expression for the
rabies virus glycoprotein in transgenic tomatoes. Bio/Technology, 13: pp. 1484-1487

PARMENTER, D.L. ET AL. 1995 - Production of biologically active hirudin in plant seeds
using oleosin partitioningYoung, M.W. - Brown, O.W. - E.M. - Curling J.M. 1997
TACKABERRY,E.- DUDANI,AK PRIOR,F.- TOCCHI,M.SARDANA,R.-
ALTOSAAR,I.- GANZ,PR. 1999 - Development of biopharmaceuticals in plant
expression systems: cloning, expression and immunological reactivity of human
cytomegalovirus glycoprotein B (UL55) in seeds of transgenic tobacco. Vaccine. 17: pp.
3020-3029 .3

TACKET, C.O., ET AL. 1998 - Immunogenicity in humans of a recombinant bacterial oI-n
antigen delivered in a transgenic potato. Nat Med, 4(5): pp. 607-9. n
n
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