Page 73 - Coespu 2020-2

The immune response in SARS- ber of individuals will be infected Imaging in Neurological Disea-
CoV-2 infection is of interest and with SARS-CoV-2, the immedia- se of Hospitalized COVID-19 Pa-
there might be a hyper infl amma- te impact on mental health could tients: An Italian Multicenter Re-
tory state similar to that seen in ha- be considerable. An acute rise in trospective Observational Study
emophagocytic lymphohisticytosis cases of delirium will probably - Abdelkader Mahammedi, Luca
in which there are increased con- prolong hospital stay; there is Saba, Achala Vagal, Michela Le-
centrations of C-reactive protein, also some preliminary eviden- ali, Andrea Rossi, Mary Gaskill,
ferritin, and interleukin-6, although ce that delirium was associated Soma Sengupta, Bin Zhang, Ales-
this state is likely to be short lived. with raised mortality in MERS. sandro Carriero, Suha Bachir,
The link between infl ammation There is a risk of common mental Paola Crivelli, Alessio Paschè, En-
and depression is well described illnesses in patients with disease rico Premi, Alessandro Padova-
in the literature, and might explain that require hospital admission, ni, Roberto Gasparotti. Published
some of the psychiatric morbidity. which might be compounded Online:May 21 2020https://doi.
Survivors of critical illness are at by the effects of social isolation. org/10.1148/radiol.2020201933
risk of persistent psychiatric im- Given this psychiatric morbidity and
pairment after discharge from high frequency of persistent fati- Psychiatric and neuropsychiatric
hospital. At 1 year, the pooled gue, some patients might have dif- presentations associated with se-
prevalences of clinically relevant fi culty in returning to their previous vere coronavirus infections: a sy-
depressive was 29%, anxiety 34%, employment, at least in the short stematic review and meta-analysis
and post-traumatic symptoms 34%. term, although physical (as well with comparison to the COVID-19
The majority of patients with severe as mental) recovery is intrinsic to pandemic - Jonathan P Rogers,
acute respiratory distress syndro- such a broad functional outcome. MRCPsych, Edward Chesney, MR-
me, a key feature of severe CO- In conclusion, although there are CPsych, Dominic Oliver, Msc, Tho-
VID-19 illness, show impairments many ways in which mental heal- mas A Pollak, PhD, Prof Philip Mc-
of memory, attention, concentra- th might be adversely affected by Guire, FmedSci, Paolo Fusar-Poli,
tion, or mental processing speed. a pandemic, my opinions are, that PhD et al. Published:May 18, 2020
None of the studies included in most people do not suffer from a DOI:https://doi.org/10.1016/
the review completed systematic psychiatric disorder following coro- S2 2 1 5 -0 3 6 6 (2 0 )3 0 2 0 3 -0 .
neuropsychological assessmen- navirus infection, and second, that
ts apart from one report of se- so far there is little to suggest that
vere SARS-CoV-2 cases, which common neuropsychiatric compli-
described a dysexecutive syn- cations beyond short-term delirium
drome in a third of survivors. are a feature. It is clear that a long
Acute respiratory distress syndrome hospitalization and to stay in ICU
and prolonged mechanical ventila- could be arise psychological and
tion are also associated with grea- neuropsychological consequences,
ter reductions in quality of life than and that is very important to assist
ICU admissions for other reasons. the patients also in this domains.
However, although the frequen-
cies of ICU admission and ven-
tilation were similar for patients References
admitted to hospital with SARS- Evidence of the COVID-19 Virus
CoV infection (13% ICU admis- Targeting the CNS: Tissue Distri-
sion and 7% ventilation) and bution, Host–Virus Interaction, and
SARS-CoV-2 (18% and 6%), they Proposed Neurotropic Mechani-
were considerably higher in pa- sms - Abdul Mannan Baig, Areeba Davide Perego
tients with MERS (60% and 51%). Khaleeq Usman Ali, Hira Syeda. Neuroscientist, Psyco-Neuro Phy-
Published online 2020 Mar 13. doi: siologist, expert in Psychopatholo-
Conclusion 10.1021/acschemneuro.0c00122 gy and neuropsychology
Given that a very large num-

73